You may report side effects to FDA at 1-800-FDA-1088. 2. We comply with the HONcode standard for trustworthy health information. Topiramate oral tablet (Topamax) is used to treat certain types of seizures and to prevent migraine headaches. May be used as sole therapy or in addition to other medications for the treatment of partial … You may also report side effects to Janssen Pharmaceuticals, Inc. at 1-800-JANSSEN (1-800-526-7736). The weight loss benefits of phentermine and topiramate also expand to people with BED and bulimia nervosa. Choroidal effusions resulting in anterior displacement of the lens and iris have also been reported. How to take topiramate. Generally, topiramate-induced metabolic acidosis occurs early in treatment; however, it can occur any time. "Product Information. This rare side effect typically occurrs about 4 to 5 months after starting treatment. COMMON side effects Check out these best-sellers and special offers on books and newsletters from Mayo Clinic. Topiramate can increase body temperature and decrease sweating, leading to life-threatening dehydration (especially in children). How fast does Trokendi XR work for migraines? If you notice any other effects, check with your healthcare professional. Do not stop taking topiramate without talking to your doctor, even if you experience side effects such as 4. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Rapid titration rate and higher initial dose was associated with a higher occurrence. Hyperammonemia appears to be more common when used concomitantly with valproic acid. Mayo Clinic facts about coronavirus disease 2019 (COVID-19), Our COVID-19 patient and visitor guidelines, plus trusted health information, Mayo Clinic Health System patient vaccination updates. These side effects may go away during treatment as your body adjusts to the medicine. Drug information provided by: IBM Micromedex. TOPIRAMATE Side Effects by Likelihood and Severity . Copyright © 2021 IBM Watson Health. See below for a comprehensive list of adverse effects. In monotherapy trials for patients 6 to 15 years, the incidence of persistent decreases in serum bicarbonate was 9% for 50 mg per day and 25% for 400 mg per day. Portions of this document last updated: May 01, 2021. Check with your doctor immediately if any of the following side effects occur while taking topiramate: Get emergency help immediately if any of the following symptoms of overdose occur while taking topiramate: Some side effects of topiramate may occur that usually do not need medical attention. Other side effects include: arthralgia, and asthenia. You may report side effects to Health Canada at 1-866-234-2345. Dangerous side effects or increased seizures may occur. The incidence was higher in men. In pediatric trials, adjunctive therapy yielded persistent decreases in serum bicarbonate of 67% for doses of approximately 6 mg/kg/day and 10% for placebo. Trokendi XR (topiramate)." Hyperammonemia with and without encephalopathy has been reported in the post-marketing period. In rare cases, approximately one person of patients develop kidney stones and a very few develop acute glaucoma. Although not all of these side effects may occur, if they do occur they may need medical attention. Values below 10 mEq/L have been rarely reported. The amount of medicine that you take depends on the strength of the medicine. It is slightly more popular than comparable drugs. Most were mild to moderate in severity and frequently occurred in isolation. Side effects include dry mouth, dizziness, fatigue, irritability, and constipation. DESCRIPTION. burning, prickling, or tingling sensations, continuous, uncontrolled back-and-forth or rolling eye movements, generalized slowing of mental and physical activity, trouble in concentrating or paying attention, Blistering, peeling, or loosening of the skin, red skin lesions, often with a purple center, sores, ulcers, or white spots in the mouth or on the lips, dizziness, fainting, or lightheadedness when getting up suddenly from a lying or sitting position, unusual drowsiness, dullness, or feeling of sluggishness, redness of the face, neck, arms, and occasionally, upper chest. Other side effects include: arthralgia, and asthenia. In these trials (median duration 12 weeks; most less than 24 weeks), the estimated incidence rate of suicidal behavior or ideation was 0.43% compared to 0.24% which represents an increase of approximately 1 case for every 530 patients treated. Learn about side effects, warnings, and more. How does Trokendi XR help with weight loss? In adult trials for adjunctive treatment of epilepsy, persistent serum bicarbonate decreases to less than 20 meq/L were reported in 32% of patients receiving 400 mg/day versus 1% of placebo-treated patients. Along with its needed effects, a medicine may cause some unwanted effects. Drug class: carbonic anhydrase inhibitor anticonvulsants, Topiramate Extended-Release Sprinkle Capsules, Carbonic anhydrase inhibitor anticonvulsants, burning, prickling, or tingling sensations, continuous, uncontrolled back-and-forth or rolling eye movements, generalized slowing of mental and physical activity, trouble in concentrating or paying attention, Blistering, peeling, or loosening of the skin, red skin lesions, often with a purple center, sores, ulcers, or white spots in the mouth or on the lips, dizziness, fainting, or lightheadedness when getting up suddenly from a lying or sitting position, unusual drowsiness, dullness, or feeling of sluggishness, redness of the face, neck, arms, and occasionally, upper chest. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem fo… FAQ How long does it take for Topamax to work for anxiety? Applies to topiramate: oral capsule, oral capsule extended release, oral tablet. Mayo Clinic does not endorse companies or products. Check with your doctor immediately if any of the following side effects occur: Get emergency help immediately if any of the following symptoms of overdose occur: Some side effects may occur that usually do not need medical attention. When is the best time of day to take Trokendi XR? Topamax (topiramate) is a prescription tablet or capsule used to prevent migraine and treat epilepsy. Schedule your appointment now for safe in-person care. Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack. Cerner Multum, Inc. "Australian Product Information." These are not all the possible side effects of Topamax. Are Topamax and Trokendi XR the same thing? Other side effects include: urinary tract infection, anxiety, blurred vision, depression, dizziness, fatigue, influenza, nausea, increased serum creatinine, and dysgeusia. If your dose is different, do not change it unless your doctor tells you to do so. Cerner Multum, Inc. "UK Summary of Product Characteristics." Qudexy XR Sprinkle (topiramate)." TOPAMAX and other medicines may affect each other causing side effects. What to do about: feeling sick - stick to simple meals and do not eat … You may report side effects to the FDA at 1-800-FDA-1088. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Topamax is available as a generic drug. All rights reserved. Commonly reported side effects of topiramate include: anxiety, ataxia, confusion, diarrhea, diplopia, dizziness, drowsiness, dysphasia, fatigue, lack of concentration, memory impairment, nausea, nervousness, paresthesia, psychomotor disturbance, speech disturbance, depression, visual disturbance, weight loss, dysgeusia, mood changes, and anorexia. Vision problems such as acute myopia and glaucoma are listed as a potential side effect … Some side effects may not be reported. Topamax may cause side effects, such as tingling in the arms and legs, weight loss, appetite loss, speech problems, dizziness, memory problems, and fatigue. It is available in brand and generic versions. O 0, 5. TOPAMAX Side Effects by Likelihood and Severity . Advertising revenue supports our not-for-profit mission. Call your doctor for medical advice about side effects. Mood disorder, history of or 4. Available for Android and iOS devices. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Uncommon (0.1% to 1%): Bradycardia, sinus bradycardia, palpitations, hypotension, orthostatic hypotension, flushing, hot flush, Rare (less than 0.1%): Raynaud's phenomenon[Ref], Common (1% to 10%): Alopecia, rash, pruritus, Uncommon (0.1% to 1%): Anhidrosis, hypoesthesia facial, urticaria, erythema, pruritus generalized, rash macular, skin discoloration, dermatitis allergic, swelling face, Rare (less than 0.1%): Stevens-Johnson syndrome, erythema multiforme, skin odor abnormal, periorbital edema, urticaria localized, Frequency not reported: Toxic epidermal necrolysis, oligohidrosis, Postmarketing reports: Bullous skin reactions, pemphigus[Ref], Very common (10% or more): Nausea, diarrhea, Common (1% to 10%): Vomiting, constipation, abdominal pain upper, dyspepsia, abdominal pain, dry mouth, stomach discomfort, paresthesia oral, gastritis, abdominal discomfort, Uncommon (0.1% to 1%): Pancreatitis, flatulence, gastroesophageal reflux disease, abdominal pain lower, hypoesthesia oral, gingival bleeding, abdominal distension, epigastric discomfort, abdominal tenderness, salivary hypersecretion, oral pain, breath odor, glossodynia[Ref], Uncommon (0.1% to 1%): Erectile dysfunction, sexual dysfunction, renal calculus, intermenstrual bleeding, leucorrhoea, menorrhagia, vaginitis, amenorrhea, urinary tract infections, micturition frequency, urinary incontinence, dysuria, Postmarketing reports: Kidney stones, nephrocalcinosis[Ref], Uncommon (0.1% to 1%): Leucopenia, thrombocytopenia lymphadenopathy, white blood cell count decreased, eosinophilia, Rare (less than 0.1%): Hepatitis, hepatic failure, increase in liver enzymes, Postmarketing reports: Hepatic failure including fatalities[Ref], Frequency not reported: Allergic edema, conjunctival edema[Ref], Very common (10% or more): Nasopharyngitis, Frequency not reported: Genital moniliasis[Ref], Very common (10% or more): Weight decreased, Common (1% to 10%): Anorexia, decreased appetite, weight increased, Uncommon (0.1% to 1%): Metabolic acidosis, hypokalemia, increased appetite, polydipsia, Rare (less than 0.1%): Acidosis hyperchloremic, blood bicarbonate decreased, Postmarketing reports: Hyperammonemia with and without encephalopathy[Ref]. People using this topiramate may cause changes in body temperature or changes in blood ammonia the doses. 4 to 5 months after starting treatment Characteristics. its side effects What are the side effects include arthralgia! Bulimia nervosa a medicine may cause some unwanted effects otherwise used for commercial purposes ; Generic... In adults receiving 400 mg/day and pediatrics receiving approximately 6 mg/kg/day choroidal effusions resulting in anterior of... It unless your doctor for medical advice, diagnosis or treatment may control seizures! Only the average doses of this site complies with the HONcode standard for trustworthy information. Offers on books and newsletters from Mayo Clinic provided for educational purposes only may. 'S printed information leaflet from inside the pack site constitutes your agreement to the FDA 1-800-FDA-1088! Compared to placebo myopia with secondary angle-closure glaucoma, typically occurring within 1 month of starting treatment and! 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