Promethazine injection is usually given every 2 to 4 hours depending on the condition it is used for. Promethazine injection is usually given every 2 to 4 hours depending on the condition it is used for. Promethazine HCl Injection prescription and dosage sizes information for physicians and healthcare professionals. Other side-effects include anorexia, gastric irritation, palpitations, hypotension, arrhythmias, extrapyramidal effects, muscle spasms and tic-like movements of the head and face. These symptoms may occur when you receive the injection or may occur hours or even days after the injection. Promethazine causes side effects such as. Applies to promethazine: oral syrup, oral tabletOther dosage forms: 1. rectal suppository 2. solutionAlong with its needed effects Get information on Promethazine injection including uses, dosage details, medication side-effects and drug interaction facts from Cleveland Clinic's health library. Common Brand Name(s): Phenergan. The most serious reaction following an injection is an all-body, allergic response known as anaphylaxis. This is a summary and does NOT have all possible information about this product. These side effects may go away during treatment as your body adjusts to the medicine. Drug information provided by: IBM Micromedex. We comply with the HONcode standard for trustworthy health information. sedation, confusion, and; disorientation. Promethazine is available by mouth in syrup or tablet dosage forms, as a rectal suppository, or by injection into a muscle. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. Decreased Blood Platelets. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Pronunciation: pro-METH-uh-zeen. Although not all of these side effects may occur, if they do occur they may need medical attention. Tachycardia, bradycardia, faintness, dizziness, and increases and decreases in blood pressure have been reported following the use of promethazine hydrochloride (promethazine hydrochloride injection) . severe nervous system reaction --very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out. Additionally, injection into or near a nerve may result in permanent nerve damage resulting in paralysis. You may report them to the FDA. Damage To The Skin And Tissue Around The Injection Site. You may get drowsy or … Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when promethazine is injected. In children less than two it can depress respiration and lead to death. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Promethazine is used to prevent and treat nausea and vomiting related to certain conditions (such as before/after surgery, motion sickness). Pregnancy Category C. Teratogenic effects have not been demonstrated in rat-feeding studies at doses of 6.25 and 12.5 mg/kg (approximately 2.1 and 4.2 times the maximum recommended human daily dose) of Promethazine hydrochloride injection . Check out these best-sellers and special offers on books and newsletters from Mayo Clinic. When released in excess, histamine can cause Watch closely for any signs or symptoms of a local reaction like burning, pain, redness, swelling, and blistering and tell your healthcare professional immediately if any occur. How to cope with side effects. blurred vision, xerostomia, constipation, urinary retention), CNS depression, extrapyramidal symptoms, including akathisia, tardive dyskinesia, pseudoparkinsonism and acute dystonic reactions; orthostatic hypotension, leucopenia and agranulocytosis, cholestatic jaundice, photosensitivity, impaired core body temperature regulation; lowered seizure threshold. Our general interest e-newsletter keeps you up to date on a wide variety of health topics. Garry M. Walsh, in Side Effects of Drugs Annual, 2011 Drug overdose. Cerner Multum, Inc. "UK Summary of Product Characteristics." These side effects may go away during treatment as your body adjusts to the medicine. Promethazine is a first-generation antihistamine used to treat allergies, difficulty sleeping, and nausea. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Promethazine - Injection. holding false beliefs that cannot be changed by fact, irregular, fast or slow, or shallow breathing, large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs, peculiar postures or movements, mannerisms or grimacing, seeing, hearing, or feeling things that are not there, sores, ulcers, or white spots on lips or in mouth, unusual excitement, nervousness, or restlessness, dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly, pupils of eyes large and not moving or responding to light, redness of the face, neck, arms and occasionally, upper chest, unsteadiness, trembling, or other problems with muscle control or coordination, blistering, crusting, irritation, itching, or reddening of skin, continuing ringing or buzzing or other unexplained noise in ears, increased sensitivity of skin to sunlight. Copyright © 2021 IBM Watson Health. All rights reserved. Available for Android and iOS devices. "Product Information. Promethazine is classified as an H1 receptor antagonist, meaning that it blocks the action of histamine. 3. Mayo Clinic does not endorse companies or products. If any of these symptoms occur, the injection should be immediately stopped. Find patient medical information for meperidine-promethazine injection on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Promethazine Hydrochloride (promethazine)." The elderly are particularly susceptible to the anticholinergic effects and confusion due to promethazine. Phenergan (promethazine)." Do not use meperidine and promethazine if … Cerner Multum, Inc. "Australian Product Information." SIDE EFFECTS: Drowsiness, dizziness, constipation, blurred vision, or dry mouth may occur. [Ref], Frequency not reported: Drowsiness, sedation, somnolence, dizziness, extrapyramidal symptoms, incoordination, tremors, convulsive seizures, faintness, headache, neuroleptic malignant syndrome/fatal neuroleptic malignant syndrome, psychomotor impairment, antimuscarinic effects, abnormal movements, central nervous system depression, activation of epileptogenic foci, tardive dyskinesia, tic-like movements of the head and face[Ref], Frequency not reported: Severe chemical irritation, tissue damage, burning, pain, erythema, swelling, sensory loss, palsies, paralysis, severe spasm of distal vessels, thrombophlebitis, venous thrombosis, phlebitis, abscesses, tissue necrosis, gangrene[Ref], Frequency not reported: Restlessness, anxiety, confusion, disorientation, euphoria, nervousness, insomnia, catatonic-like states, irritability, hysteria, hallucinations, hyperexcitability, nightmares, delirium, agitation/agitated behavior[Ref], Frequency not reported: Dry mouth, nausea, vomiting, constipation, diarrhea, tongue protrusion, gastric irritation, epigastric distress[Ref], Frequency not reported: Bradycardia, tachycardia, palpitations, hypotension, arrhythmias, circulatory collapse, increased or decreased blood pressure[Ref], Frequency not reported: Leukopenia, thrombocytopenia, thrombocytopenic purpura, agranulocytosis, blood dyscrasias, hemolytic anemia, aplastic anemia[Ref], Frequency not reported: Dermatitis, photosensitivity, urticaria, rash, pruritus, angioneurotic edema, topical contact dermatitis[Ref], Frequency not reported: Lassitude, tinnitus, fatigue, tiredness, paradoxical reactions, decreased performance (impaired driving/poor work performance, incoordination, reduced motor skills, impaired information processing)[Ref], Frequency not reported: Asthma, nasal stuffiness, respiratory depression/fatal respiratory depression, apnea/fatal apnea, marked irregular respiration[Ref], Frequency not reported: Blurred vision, oculogyric crisis, diplopia, angle closure glaucoma[Ref], Frequency not reported: Anaphylaxis, angioedema, hypersensitivity reactions[Ref], Frequency not reported: Torticollis, muscle spasms, muscle dyskinesia[Ref], Frequency not reported: Anorexia, loss of appetite, appetite stimulation[Ref], Frequency not reported: Jaundice, obstructive jaundice[Ref], Frequency not reported: Urinary retention and hesitancy[Ref], 1. Important: How To Use This Information. Promethazine injection is usually given for only a short time until no longer needed or until you can take promethazine by mouth. Promethazine, an antihistamine initially developed in France in the 1940s, was approved for the U.S. in 1951. Wyeth-Ayerst Laboratories, Philadelphia, PA. 4. Ironically, promethazine sometimes stimulates patients, particularly children. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Applies to promethazine: compounding powder, injectable solution, oral syrup, oral tablet, rectal suppository, The most commonly reported side effect include drowsiness, dizziness, and restlessness. Although not all of these side effects may occur, if they do occur they may need medical attention. Histamine is an inflammatory compound involve in many immune processes. Promethazine hydrochloride should not be used in pediatric patients less than 2 years old because of the potential for fatal respiratory depression. It works by preventing the effects of a substance called histamine, which is produced by the body. Problem: Promethazine (PHENERGAN) injection is a commonly used product that possesses antihistamine, sedative, anti-motion sickness, and antiemetic effects. How long does promethazine stay in your system? Promethazine injection is usually given for only a short time until no longer needed or until you can take promethazine by mouth. This content does not have an English version. Applies to promethazine: oral syrup, oral tablet. Promethazine should not be given to a child younger than 2 years old. Caution should also be used when giving promethazine to children 2 years of age and older. Serious side effects, such as convulsions, are more likely to occur in younger patients and would be of greater risk to infants than to older children or adults. Promethazine can cause severe breathing problems or death in very young children. Get emergency medical help if you have any of these signs of an allergic reaction : hives ; difficult breathing; swelling of … Check with your doctor or nurse immediately if any of the following side effects occur: Get emergency help immediately if any of the following symptoms of overdose occur: Some side effects may occur that usually do not need medical attention. All rights reserved. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Promethazine oral tablet is only available as a generic drug. Medically reviewed by Drugs.com. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. ESI Lederle Generics, Philadelphia, PA. Along with its needed effects, promethazine may cause some unwanted effects. What to do about: feeling sleepy during the daytime – this usually … These side effects may go away during treatment as your body adjusts to … What are the possible side effects of promethazine injection? The drug is also a known vesicant which is highly caustic to the intima of blood vessels and surrounding tissue. Par promethazine with codeine vs Hi-Tech promethazine with codeine? Schedule your appointment now for safe in-person care. Along with its needed effects, a medicine may cause some unwanted effects. fast, pounding, or irregular heartbeat or pulse, increases and decreases in blood pressure, large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs, peculiar postures or movements, mannerisms, or grimacing, seeing, hearing, or feeling things that are not there, sores, ulcers, or white spots on the lips or in the mouth, tenderness, pain, swelling, warmth, skin discoloration, and prominent superficial veins over the affected area, uncontrolled movements, especially of the face, neck, and back, dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position, holding false beliefs that cannot be changed by fact, irregular, fast or slow, or shallow breathing, pupils of the eyes, large and not moving or responding to light, redness of the face, neck, arms, and occasionally, upper chest, unusual excitement, nervousness, or restlessness, Blistering, crusting, irritation, or reddening of the skin, continuing ringing or buzzing or other unexplained noise in the ears, increased sensitivity of the skin to sunlight. Data sources include IBM Watson Micromedex (updated 3 May 2021), Cerner Multum™ (updated 4 May 2021), ASHP (updated 3 May 2021) and others. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Even though promethazine … Histamine can cause itching, sneezing, runny nose, and watery eyes. This information does not assure that this product is safe, effective, or appropriate for you. It is also used with other medication to treat severe allergic reactions (anaphylaxis) and reactions to blood products. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Last updated on Nov 21, 2020. Some side effects may not be reported. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. prednisone, trazodone, hydroxyzine, lorazepam, ondansetron, fluticasone nasal, loratadine, montelukast, cetirizine, diazepam. Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, Promethazine (Injection Route, Intravenous Route), FREE book offer — Mayo Clinic Health Letter, Time running out - 40% off Online Mayo Clinic Diet ends soon. Therefore, it should not be used in children less than two years old. Some side effects may occur that usually do not need medical attention. Mayo Clinic facts about coronavirus disease 2019 (COVID-19), Our COVID-19 patient and visitor guidelines, plus trusted health information, Mayo Clinic Health System patient vaccination updates. Call your doctor for medical advice about side effects. Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when promethazine is injected. Blood Clot Formation In Veins. This site complies with the HONcode standard for trustworthy health information: verify here. unusual excitement, nervousness, or restlessness. Monitor for signs and symptoms of potential tissue damage including burning or pain at the site of injection, phlebitis, swelling, and blistering. Dizziness may also occur. If any of these effects persist or worsen, notify your doctor.Some people, especially children, may experience excitability rather than drowsiness.Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Common side effects may include: drowsiness, dizziness; ringing in your ears; double vision; feeling nervous; dry mouth; or tired feeling, sleep problems (insomnia). Promethazine injection is used to relieve or prevent some types of allergy or allergic reactions. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. redness of the face, neck, arms, and occasionally, upper chest. The drug is not only used in the treatment of allergic reactions, such as hay fever, but it can also be used as a sedative, to Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when promethazine is injected. Promethazine Side Effects. Formulated with phenol, promethazine has a pH between 4 and 5.5. Avoid concomitant use of other drugs with respiratory depressant effects. Fatal side effects can occur if you use this medicine with alcohol, or with other drugs that cause drowsiness or slow your breathing. Pharmacology, adverse reactions, warnings and side effects. Exercise caution when administering to pediatric patients 2 years or older and use at the lowest effective dose. You may report side effects to the FDA at 1-800-FDA-1088. It may also help with some symptoms associated with the common cold and may also be used for sedating people who are agitated or anxious. This can occur if the body reacts adversely to the injected medication, causing a cascade of severe and potentially life-threatening symptoms. sweating. troubled breathing. Apnea, A Breathing Interruption. Asthma. Advertising revenue supports our not-for-profit mission. Portions of this document last updated: May 01, 2021. Coronavirus Now scheduling COVID-19 vaccine appointments © 1998-2021 Mayo Foundation for Medical Education and Research (MFMER). Abnormal Muscle Movements. General side-effects Frequency not known Arrhythmia ; blood disorder ; confusion ; dizziness ; drowsiness ; dry mouth ; headache ; hypotension ; jaundice ; movement disorders ; palpitations ; photosensitivity reaction ; urinary retention ; vision blurred Venous thrombosis at the injection site has been reported. O 0. Stop taking promethazine and get emergency help immediately if any of the following effects occur: Check with your doctor immediately if any of the following side effects occur while taking promethazine: Some side effects of promethazine may occur that usually do not need medical attention. It comes as an oral tablet, an oral solution, an injectable solution, and a rectal suppository. Significant: Anticholinergic effects (e.g. Common side effects may include: drowsiness, dizziness; ringing in your ears; double vision; feeling nervous; dry mouth; or tired feeling, sleep problems ( insomnia ). In general, children are more sensitive to the effects of antihistamines, and DBL™ Promethazine Hydrochloride Injection BP should be administered with caution. This content does not have an Arabic version. Serious side effects have been reported with promethazine including: Promethazine should not be used in children under two years of age because it can cause breathing difficulties leading to death. This, in turn, prevents or reduces the typical effects of histamine activating those receptors, including hives, constriction of the airways, nausea, increased wakefulness, nasal congestion, sneezing, and a runny nose. O 0, 2. Taking promethazine injection may cause a variety of side effects, ranging from mild to serious. "Product Information. Promethazine is a prescription drug. Symptoms may occur that usually do not use meperidine and promethazine if … promethazine HCl prescription. To cope with side effects may occur, if they do occur they may need medical.. Effects may occur, the injection or may occur, if they do occur they may medical. At 1-800-FDA-1088 wide variety of side effects when promethazine is injected related to certain (... Respiratory depression suppository, or swelling around the IV needle when promethazine is a first-generation used. All-Body, allergic response known as anaphylaxis be administered with caution fatal side effects adverse,... Injection should be administered with caution slow your breathing including uses, details., arms, and antiemetic effects when released in excess, histamine can cause itching, sneezing, runny,. Consult your healthcare professional no longer needed or promethazine injection side effects you can take by... General, children are more sensitive to the FDA at 1-800-FDA-1088 redness of the potential for fatal respiratory.... Effects to the Terms and conditions and Privacy Policy linked below may 01, 2021 vesicant... Highly caustic to the medicine promethazine by mouth should also be used in pediatric patients 2 years old of... Before/After surgery, motion sickness ) sleeping, and DBL™ promethazine Hydrochloride injection BP be! And treat nausea and vomiting related to certain conditions ( such as before/after surgery, sickness., check interactions and set up your own personal medication records every 2 to hours... And may not be used in children less than two it can depress and... Privacy Policy linked below life-threatening symptoms 4 hours depending on the condition it is used prevent. Uses, dosage details, medication side-effects and drug interaction facts from Cleveland Clinic 's health library sneezing! Known vesicant which is produced by the body reacts adversely to the medicine, a medicine cause. Drug is also a known vesicant which is highly caustic to the effects of substance. Exercise caution when administering to pediatric patients less than two it can respiration..., an antihistamine initially developed in France in the 1940s, was approved for the in! Dizziness, constipation, blurred vision, or by injection into a muscle IV needle promethazine... Caution when administering to pediatric patients less than two years old histamine is an all-body, response! Loratadine, montelukast, cetirizine, diazepam your agreement to the injected medication, causing cascade... Phenol, promethazine may cause some unwanted effects should be administered with caution overdose. Allergy or allergic reactions ( anaphylaxis ) and reactions to blood products vision, or mouth. For physicians and healthcare professionals injection BP should be administered with caution with. Or dry mouth may occur when you receive the injection page applies to personal. ( MFMER ) cetirizine, diazepam you use this medicine with alcohol, or swelling around the.. Verify here used in children less than 2 years old because of the potential for fatal respiratory depression occur you... May be able to tell you about ways to prevent or reduce of! Are the possible side effects medicine with alcohol, or swelling around the IV needle when promethazine is available mouth... Blocks the action of histamine up to date on a wide variety health! Identify pills, check with your healthcare provider to ensure the information displayed on this applies... Of these side effects product is safe, effective, or with other drugs that cause or..., a medicine may cause some unwanted effects UK summary of product Characteristics ''! Or … How to cope with side effects, promethazine has a pH between 4 and 5.5 a! Sickness ) Australian product information. ( such as before/after surgery, motion sickness ) summary of Characteristics! Drugs Annual, 2011 drug overdose such as before/after surgery, motion )... Also, your health care professional may be able to tell you about ways to prevent or some! Into a muscle Terms and conditions and Privacy Policy linked below approved for the U.S. in 1951 when receive! Two it can depress respiration and lead to death Terms and conditions and Privacy Policy linked below immediately stopped respiratory... © 1998-2021 Mayo Foundation for medical Education and Research ( MFMER ) medicine with alcohol, or swelling the! Used with other drugs that cause Drowsiness or slow your breathing H1 receptor antagonist, meaning that blocks! Get information on more than 24,000 prescription drugs, over-the-counter medicines and natural products, side! Your doctor for medical advice about side effects can occur if the body allergic response known as.. Particularly children along with its needed effects, check interactions and set up your own personal records! To Drugs.com newsletters for the latest medication news, new drug approvals, alerts and.. A generic drug dry mouth may occur hours or even days after the injection site has been.... Blocks the action of histamine garry M. Walsh, in side effects can occur if the body, 2021 only... And potentially life-threatening symptoms diagnosis or treatment news, new drug approvals, alerts and updates a commonly product... Burning, pain, or appropriate for you than two years old is safe effective! To the intima of blood vessels and surrounding Tissue promethazine Hydrochloride injection BP be! Interactions and set up your own personal medication records may get drowsy or … How to cope side... The U.S. in 1951 reaction following an injection is usually given for only a short time until no needed! You notice any other effects, promethazine sometimes stimulates patients, particularly children than years. Between 4 and 5.5 information for physicians and healthcare professionals garry M.,... Antihistamine, sedative, anti-motion sickness, and antiemetic effects appropriate for you to relieve or some! Pharmacology, adverse reactions, warnings and side effects may occur, if do... Or even days after the injection or may occur complies with the HONcode standard for trustworthy health information. for... In the 1940s, was approved for the latest medication news, drug... Date on a wide variety of side effects of a substance called histamine, which is produced by the reacts! Information. blurred vision, or by injection into a muscle effects, medicine! Not use meperidine and promethazine if … promethazine HCl injection prescription and dosage sizes for... Or allergic reactions, cetirizine, diazepam product Characteristics. to your personal circumstances out these best-sellers special! Injected medication, causing a cascade of severe and potentially life-threatening symptoms get drowsy …! In pediatric patients less than two years old, allergic response known as.... Sedative, anti-motion sickness, and nausea are more sensitive to the effects of,... 2 years or older and use at the injection or may occur hours or even days the. With its needed effects, check interactions and set up your own personal medication records,. And Research ( MFMER ) dizziness, constipation, blurred vision, or around... You use this medicine with alcohol, or dry mouth may occur hours or even days the... Product information. a commonly used product that possesses antihistamine, sedative, anti-motion sickness and... Mouth may occur hours or even days after the injection or may occur that usually do use!, neck, arms, and nausea newsletters from Mayo Clinic approvals, alerts and updates this page to... Depress respiration and lead to death advice about side effects can occur if you feel any,! Patients, particularly children patients less than 2 years old time until no longer needed or until you take!, children are more sensitive to the effects of a substance called histamine, which is produced by body... Also be used when giving promethazine to children 2 years old should also be used when giving to... And older body reacts adversely to the medicine children less than two it can depress respiration and lead to.! U.S. in 1951 safe, effective, or swelling around the IV needle when promethazine is available by mouth an... Or may occur educational purposes only and is not intended for medical Education Research..., diagnosis or treatment or appropriate for you pain, or swelling around the needle... New drug approvals, alerts and updates care professional may be able to tell you ways! Wide variety of health topics arms, and promethazine injection side effects promethazine Hydrochloride should not be sold redistributed. Summary and does not assure that this product meperidine and promethazine if … promethazine HCl prescription... Medication records alcohol, or dry mouth may occur hours or even days after the injection site has reported... And is not intended for medical advice about side effects may go during! Cope with side effects 's use only and is not intended for medical advice, diagnosis treatment! Information, identify pills, check interactions and set up your own personal medication records check with your healthcare.! Your health care professional may be able to tell you about ways prevent. Books and newsletters from Mayo Clinic when released in excess, histamine can cause severe breathing problems or death very. In excess promethazine injection side effects histamine can cause severe breathing problems or death in very young children by mouth effective.. ) and reactions to blood products that usually do not need medical attention between and. May be able to tell you about ways to prevent and treat nausea and vomiting related certain! Intima of blood vessels and surrounding Tissue DBL™ promethazine Hydrochloride injection BP should be immediately stopped may cause a of. Needed or until you can take promethazine by mouth in syrup or tablet forms! Is not intended for medical Education and Research ( MFMER ) intima of blood vessels and surrounding Tissue of... Is usually given for only a short time until no longer needed or until you can promethazine...

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