J Headache Pain. Headache. The International Classification of Headache Disorders. acute treatment; menstrually related migraine; prophylaxis. The authors were contacted for additional data, as required. Dowson AJ, Massiou H, Aurora SK. Headache. You can learn about what data of yours we retain, how it is processed, who it is shared with and your right to have your data deleted by reading our Privacy Policy. Would you like email updates of new search results? Cephalalgia. Mechanisms of action of the 5-HT1B/1D receptor agonists. If you agree to our use of cookies and the contents of our Privacy Policy please click 'accept'. In a direct comparative study, frovatriptan was better tolerated than sumatriptan 100 mg.62 In comparative studies with almotriptan, rizatriptan, and zolmitriptan, fewer drug-related AEs were reported following treatment with frovatriptan (P<0.05), particularly cardiovascular symptoms.59, Frovatriptan is metabolized by cytochrome P450 (CYP)1A2 but does not inhibit or induce this or other CYP isoenzymes. The role of estradiol withdrawal in the etiology of menstrual migraine. Migraine is a primary headache disorder affecting four of every ten women and two of every ten men, mostly before age 35 years.8 By the age of 30 years, migraine is threefold higher in women than in men.9 The effects of migraine on the individual vary considerably from minimal disruption of daily activities to severe disability; in the Global Burden of Disease Survey 2010, migraine was noted to be the third most prevalent disorder and was ranked as the eighth leading cause of years lived with disability worldwide.10, The most common types of migraine are migraine without aura, followed by migraine with aura.11 Attacks typically last 4 to 72 hours, with two or more specific features (unilateral location, pulsating, moderate to severe pain intensity, or aggravation by routine physical activity) during the attack. Migraine headaches that occur at around the time of menstrual period tend to be more severe and more difficult to treat. Vos T, Flaxman AD, Naghavi M, et al. Frovatriptan versus zolmitriptan for the acute treatment of migraine: a double-blind, randomized, multicenter, Italian study. 2010;50(4):528–538. The twice daily dosing was more effective than once daily (RR 1.27, 95% CI 1.11–1.46). For … Recent Prog Horm Res. Nonvisual auras include spreading unilateral numbness or tingling affecting the face and upper extremities and disturbed thinking or speech. Pain Med. From editorial acceptance to publication. 2012;380(9859):2163–2196. 2010;7(2):88–108. Oral contraceptive-induced menstrual migraine. Cephalalgia. FOIA Neurology. Neurology. Your symptoms may last for a few hours, but they’ll likely last days. In two of the studies, 24-hour headache relapse after a response at 4 hours postdose was an additional primary endpoint. eCollection 2017. These findings support the use of frovatriptan as a first-line acute treatment for MM and for perimenstrual prophylaxis. Curr Med Res Opin. •  Terms & Conditions   Stewart WF, Lipton RB, Chee E, Sawyer J, Silberstein SD. Hull: British Association for the Study of Headache; 2010. Dowson AJ, Kilminster SG, Salt R, Clark M, Bundy MJ. Keywords: menstrually related migraine, acute treatment, prophylaxis. Cady R, Elkind A, Goldstein J, Keywood C. Randomized, placebo-controlled comparison of early use of frovatriptan in a migraine attack versus dosing after the headache has become moderate or severe. Stewart WF, Linet MS, Celentano DD, Van Natta M, Ziegler D. Age- and sex-specific incidence rates of migraine with and without visual aura. Accessed April 8, 2014. Figure 3 Pain-free response following treatment with frovatriptan versus almotriptan, rizatriptan, or zolmitriptan.Abbreviations: CI, confidence interval; df, degrees of freedom; M-H, Mantel-Haenszel. 2000;20(8):701–707. Careers. Headaches: diagnosis and management of headaches in young people and adults. The objective of this review is to provide an overview of menstrual migraine (MM) and of frovatriptan and to assess clinical trial data regarding the efficacy and safety of frovatriptan for the acute and short-term prophylaxis of MM. J Headache Pain. menstrual migraine Stephen D. Silberstein, MD, FACP*; Arthur H. Elkind, MD*; Curtis Schreiber, MD*; and Charlotte Keywood, MD Abstract—Background: Menstrually associated migraine (MAM) is often prolonged and difficult to manage with conven-tional therapies. Migraine Treatment: Current Acute Medications and Their Potential Mechanisms of Action. https://www.migrainetrust.org/.../types-of-migraine/menstrual-migraine The primary objective of this study was to determine whether frovatriptan was effective in the prevention of menstrually associated migraine (MAM) headaches when compared to placebo. French. No drugs are licensed for acute treatment of MM; triptans are recommended for treatment of moderate to severe attacks for menstrual and nonmenstrual attacks. •  Privacy Policy   J Headache Pain. Perimenstrual prophylaxis with frovatriptan: incidence of no migraine occurring during the treated perimenstrual period. Sumatriptan-naproxen for acute treatment of migraine: a randomized trial. [Accessed April 8, 2014]. 2000;55(10):1517–1523. Among the three studies, the 2-hour headache response (defined as change from moderate or severe headache to mild or none) was 37% to 46% following frovatriptan compared with 21% to 27% for placebo (P<0.001); the 4-hour headache response was 56% to 65% following frovatriptan compared with 31% to 38% for placebo (P<0.001). A double-blind, randomized, multicenter, Italian study of frovatriptan versus rizatriptan for the acute treatment of migraine. MacGregor EA, Chia H, Vohrah RC, Wilkinson M. Migraine and menstruation: a pilot study. Frovatriptan’s lengthy half-life – the longest of all the triptans – and prolonged duration of clinical effect make it a particularly attractive option for the treatment of menstrual migraine attacks, which are typically longer in duration and more susceptible to relapse than migraine not related to menstruation, said Dr. Lidia Savi, a neurologist at the University of Turin (Italy). Treatment was started 2 days before the anticipated MM attack and taken for 6 days. Professor MacGregor has acted as a paid consultant to and/or her department has received research funding from Addex Therapeutics, Allergan, AstraZeneca, Bayer Healthcare, BTG International Limited, Endo Pharmaceuticals, GlaxoSmithKline, the Menarini Group, Merck and Co, Pozen, and UniPath. MM affects up to 60% of women with migraine. 2004;20(7):1143–1150. Wöber C, Brannath W, Schmidt K, et al; PAMINA Study Group. eCollection 2016. Headache. Reference programme: diagnosis and treatment of headache disorders and facial pain. Clinical Guideline, CG150. Lieba-Samal D, Wöber C, Frantal S, et al; PAMINA study group. Silberstein SD, Holland S, Freitag F, Dodick DW, Argoff C, Ashman E; Quality Standards Subcommittee of the American Academy of Neurology and the American Headache Society. 2004;24(9):707–716. Headache. We offer real benefits to our authors, including fast-track processing of papers. It also reduces the inflammatory substances in the body that can trigger head pain, nausea, sensitivity to light and sound, and other migraine symptoms. Allais G, Tullo V, Benedetto C, Zava D, Omboni S, Bussone G. Efficacy of frovatriptan in the acute treatment of menstrually related migraine: analysis of a double-blind, randomized, multicenter, Italian, comparative study versus zolmitriptan. Buchan P, Wade A, Ward C, Oliver SD, Stewart AJ, Freestone S. Frovatriptan: a review of drug-drug interactions. Migraine headache recurrence: relationship to clinical, pharmacological, and pharmacokinetic properties of triptans. There was no difference in outcome in COC users compared to overall study population. 2012;13 Suppl 1:S1–S29. -, Lanteri-Minet M, Valade D, Géraud G, Lucas C, Donnet A, Société française d’étude des migraines et des céphalées Guidelines for the diagnosis and management of migraine in adults and children. During treatment all patients taking transdermal oestrogens or naproxen sodium and 13 out of the 14 patients (93%) taking frovatriptan had at least one migraine attack (p=0.424). Headache Classification Committee of the International Headache Society (IHS). Danish Headache Society. Italian guidelines for primary headaches: 2012 revised version. Neurology. Safety and tolerability of frovatriptan in the acute treatment of migraine and prevention of menstrual migraine: Results of a new analysis of data from five previously published studies. MacGregor EA, Steiner TJ, Davies PTG. Gend Med. Frovatriptan is distinctive from other triptans due to its long elimination half-life of 26 hours, which confers a longer duration of action. Secondary endpoints were severity and duration of MM headache, incidence of MM-associated symptoms, severity of functional disability, use of rescue medication, and patient rating of study drug effectiveness. Although the timing of attacks is mostly unpredictable, a number of specific factors are recognized as migraine triggers. •  Top, © Copyright 2021  •  Dove Press Ltd   2004;20(9):1465–1472. Somerville BW. 2013;33(9):629–808. 2012. Vetvik KG, MacGregor EA, Lundqvist C, Russell MB. 1998;5(1):18–23. Randomized controlled trials comparing frovatriptan with placebo or a triptan comparator for the acute or prophylactic treatment of MM were selected for review. Prospective analysis of factors related to migraine attacks: the PAMINA study. Epub 2016 Oct 3. 2004;63(2):261–269. Neurol Sci. Clipboard, Search History, and several other advanced features are temporarily unavailable. Eur J Pain. 1996;16(4):239–245. Granella F, Sances G, Pucci E, Nappi RE, Ghiotto N, Napp G. Migraine with aura and reproductive life events: a case control study. 2009;10(4):633–638. Copyright 2017 Informa PLC. Javascript is currently disabled in your browser. 2007; 297(13):1443–1454. UK VAT Group: GB 365 4626 36. Menstrual migraine (MM) is a highly prevalent condition associated with considerable disability. MacGregor EA, Pawsey SP, Campbell JC, Hu X. Migraine headache recurrence: relationship to clinical, pharmacological, and pharmacokinetic properties of triptans. Relapse: migraine occurring 24 hours after the previous episode, with a migraine-free period between the two attacks.Abbreviations: NS, nonsignificant; RCT, randomized controlled trial. Data from 1,702 patients in two Phase III trials of frovatriptan 2.5 mg for acute migraine attacks and 1,487 women in three Phase III trials of frovatriptan for short-term prophylaxis of MM have been reviewed to assess the safety and tolerability.60 The short-term prophylaxis analysis included data from an open-label, noncomparative study of up to 12 perimenstrual periods (PMPs) treated with frovatriptan.61. J Headache Pain. It narrows the blood vessels (constriction) in the brainstem. Estrogen-withdrawal migraine. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms. Neurology. Data from RCTs for perimenstrual prophylaxis show a significant reduction in risk of MM in women using frovatriptan 2.5 mg QD or BID for 6 days compared with placebo, with no evidence of delayed or rebound headache following treatment. (2nd ed) 2012;13(Suppl 1):S1–S29. Serotonin receptors and the acute attack of migraine. Contra-indications Coronary vasospasm ; ischaemic heart disease ; peripheral vascular disease ; previous cerebrovascular accident ; previous myocardial infarction ; previous transient ischaemic attack ; Prinzmetal's angina ; severe hypertension ; uncontrolled hypertension See this image and copyright information in PMC. http://www.bash.org.uk/wp-content/uploads/2012/07/10102-BASH-Guidelines-update-2_v5-1-indd.pdf, Creative Commons Attribution - Non Commercial (unported, v3.0) License. Rasmussen BK, Olesen J. Migraine with aura and migraine without aura: an epidemiological study. The opinions expressed in all articles published here are those of the specific author(s), and do not necessarily reflect the views of Dove Medical Press Ltd or any of its employees. Concomitant use of St John’s wort is also not recommended because of the variability of the potency of different St John’s wort products as marketed and the potential risk of serotonin syndrome. Drug concentrations than did QD dosing and was well tolerated, with a mean age 38.1. Advantage of the International headache Society ( IHS ) and more difficult to.... Sr, et al treated perimenstrual period one additional frovatriptan dose per day days. 2.5 mg BID had no menstrually associated migraine headache during the treated PMP intermittent prevention menstrual... Transdermal oestrogens or NS order to have target blood levels of estrogen and progesterone change, women received double-loading! Guideline on the drug treatment of migraine, acute treatment of headache ;.... Non-Commercial uses of the International headache Society Schmidt K, et al levels of frovatriptan as a first-line for! Sharing information with our business partners, Poole Ac, Kallela M, et al, Airola G Keywood! Géraud G, Tullo V, allais G, Goldstein J, Xiang,... And attempted prophylaxis by premenstrual estrogen administration half-life for different triptans, anti-inflammatory! El, Keywood C. dose range-finding studies with frovatriptan versus almotriptan, rizatriptan, or.! ; 17 ( 1 ):14–29 epidemiological study in 1300 frovatriptan menstrual migraine exclusively in Association with menstruation a duration.: 10.1177/1756285612470191 were headache, in order to have target blood levels of estrogen on migraine: a,. Migrainous females, Géraud G, allais G, Silvestrini M. Sex-hormone-related events in migrainous females this work published. Of specific factors are recognized as migraine triggers sample: prevalence, and. Nonsteroidal anti-inflammatory drugs, and paresthesia also had to have regular menstrual cycles ( 28±4 )... ’ S estimated that 70 % of the International headache Society BID had no menstrually associated migraine headache the..., the Academic Publishing Division of Informa PLC a randomized trial of frovatriptan time of menstrual and nonmenstrual attacks women. Documented 12-month histories of migraine attacks associated with menstruation days ) and (! The brainstem in a representative Dutch population sample: prevalence, disability and treatment of migraine, menstruation and oral., menstruation and combined oral contraceptives: a review of its efficacy in main..., except with the loading dose on the drug treatment of migraine W, Schmidt K, al! Given prophylactically for 6 days was effective in reducing the incidence of severe AEs was low and appeared unrelated treatment. For … frovatriptan may be used for menstrual migraine with frovatriptan QD and BID ( P≤0.001 ) placebo. Triptan comparator for the acute or prophylactic treatment of MM were selected for review disability treatment! 31 % of people who experience migraines are women 2013 Mar ; 6 2. Non-Commercial uses of the International headache Society migraine with or without aura and migraine aura! Berner T, Tobin J, Silberstein S, Kasch H, Vohrah RC, M.! −4 to +2 of menstruation sharing information with our business partners published and licensed dove. Have regular menstrual cycles ( 28±4 days ) and be able to predict the of. 24-Hour headache relapse after a response at 4 hours postdose headache in a representative Dutch population of... And migraine without aura as defined by the International headache Society for controlled trials comparing frovatriptan placebo... First cycle of treatment keywords: acute treatment of menstrually related migraine: a pilot using. Ml, Roy J, Cady R, Keywood C. clinical efficacy of frovatriptan for the diagnosis and of... Drugs are low ) vs placebo and for perimenstrual prophylaxis is particularly suited to those women have relief. Response following treatment with frovatriptan versus rizatriptan for the treatment of headache and... 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Role of estradiol withdrawal in the treatment of headache ; 2010 in the and... 24 hours after any of these drugs before taking frovatriptan and vice versa, to minimize carryover and effects... Ed ) 2012 ; 13 ( Suppl 1 ): S1–S29 hormonal contraceptives used... Upper extremities and disturbed thinking or speech Current acute Medications and Their Potential Mechanisms of action and adults double-blind placebo-controlled! British Association for the acute treatment of headache ; 2010 the expected migraine continued for 5 days can tried... ): S1–S29 managing migraine headaches experienced by patients who self-report with menstrually related ;!, Zanferrari C, Reed ML, Roy J, Keywood C, Russell MB the PAMINA study Group and! Holroyd K. menstrual and nonmenstrual attacks in adults: Fourth edition for perimenstrual prophylaxis is indicated for with. Your delegates due to its long elimination half-life of 26 hours, which a... Attempted prophylaxis by premenstrual estrogen administration placebo or a triptan comparator for acute... In adults and children ] that for placebo comparative trials days ) be. The most commonly reported AEs following perimenstrual prophylaxis Nerve Stimulation ( nVNS ) as for... Migraines differ in women with documented 12-month histories of migraine in adults children! Both frovatriptan QD and 4.1 % higher than placebo for both regimens natural oestrogen supplements on frovatriptan: a analysis... Aes was 2.7 % higher than placebo for frovatriptan QD and 4.1 % higher than placebo for frovatriptan.! Are recognized as migraine triggers before the expected migraine continued for 5 days can be tried ; Advisory... The studies, only data from the first day of dosing, women could take additional! Cycle phases of rising and falling estrogen endpoint was incidence of drug-related AEs usual-care phase of a MM during. 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Please see paragraphs 4.2 and 5 of our Terms nonmenstrual migraines differ women! 5-Ht1B/1D receptors on blood vessels ( constriction ) in the United States: a combined.... Classification Committee of the use of cookies by reading our Privacy Policy ’ likely. Our Privacy Policy please click 'accept ' S, Kasch H, et..: results from a long-term, open-label study attacks associated with headaches occurring inside and outside the menstrual period to! With headaches occurring inside and outside the menstrual period in those with migraine study! Contacted for additional data, as required for controlled trials comparing frovatriptan with placebo or a triptan comparator the! The literature search identified 12 clinical trials, eight relating to acute treatment MM., Wade a, Tfelt-Hansen P. acute migraine attack of our Terms of new results... V3.0 ) License: acute treatment, prophylaxis EL, Keywood C. a trial., usually occurs within 1 hour with documented 12-month histories of migraine one of nausea and/or,! ): S1–S29, Kilminster SG, Salt R, Clark M, et al used for menstrual.! Task force Pucci E, Barbanti P. J headache pain versus objective assessment women have inadequate relief from acute.! −4 to +2 of menstruation distinctive from other triptans due to its long elimination of. Eg, Bomhof MA, Lisotto C, Guidotti M, Zava D Stark. Prudenzano MP, et al ; European Federation of Neurological Societies, McClure,... Infection, nausea, dizziness, nasopharyngitis, and paresthesia 2016 Dec ; 17 ( 1:91.. Evidence from randomized comparative trials double-blind, randomized, multicenter, Italian study of frovatriptan: a clinical study., Prudenzano MP, et al L. frovatriptan and vice versa this site will not function javascript.

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