The father of the Celtic pantheon, he is associated with fertility and magic, a large and powerful but often brutish figure. Before Oisín Biotechnologies and OncoSenX, Scholz founded — and became the CEO of — Immusoft. This fundamental attribute can be particularly problematic when the drug is a poison designed to kill cells. Conceived by Gobel, the NOA was launched in 2011. Working with Robert Young, who is a gerontology consultant and researcher known for validating supercentenarians, Coles and Dr. Stanley Primer determined that the cause of death is senile systemic amyloidosis (SSA). He says, “You can quite easily write a genetic program that says ‘if you’re a p16+ myocyte, but not a cardiomyocyte, then die’. In Shin Megami Tensei however, he's a manipulative and arrogant figure who acts as one of the main characters in SMT IV: Apocalypse. In 390 BC the Celts became the only ancient civiliation to ever capture Rome; … The particular character of the Dagda was as a figure of burlesque lampoonery in Irish mythology, and some authors even conclude that he was trusted to be benevolent enough to tolerate jokes at his own expense. Less is known about the pre-Christian mythologies of Britain than those of Ireland. Oisín’s approach, on the other hand, takes targeting out of the realm of chemistry and brings it into the realm of information. The Morrígan was a tripartite battle goddess of the Celts of Ancient Ireland and Scotland. He considers them to be limited by their toxicities. In 2014 the Methuselah Foundation sponsored and contributed to the OPA. The problem with this approach is that sometimes the molecule can interact with things it wasn’t intended to, or it interacts with the correct target but in a cell population or organ where it is not needed or is harmful. “We have several partners and a large investor network of mission-oriented individuals who want to see medical breakthroughs move from the academic research setting into the clinic. ‘ Dagda claims that Nanashi has accomplished nothing in his short life, but that together the two of them could change … Inspired by the 300 Spartans who held the pass at Thermopylae in 480 B.C., Gobel created The 300. Telomeres are regions of repetitive nucleotide sequences at the ends of chromosomes. They are now conducting experiments that will show that the approach improves health and increases lifespan in organisms ranging from mice to primates. So, I had a chat with Matthew Scholz, co-founder and CEO of Oisín Biotechnologies, to learn more about their platform technology. The first-century Roman poet Lucan mentions the gods Taranis, Teutates and Esus, but there is little Celtic evidence that these were important deities. Among these are images of a three-headed or three-faced god, a squatting god, a god with a snake, a god with a wheel, and a horseman with a kneeling giant. Indeed, in 2016 researchers at the Mayo Clinic reported this approach extended the life of mice by up to 25%. In Celtic mythology, what was the purpose of the warrior-goddess Morrigan? In mouse longevity studies, Oisín has shown a significant synergistic effect from killing p53+ and p16+ cells. The horseman with the kneeling giant is centered on either side of the Rhine. -Funded bowhead whale genome sequencing at University of Liverpool, -Co-organized and co-funded events at White House Meeting on Regenerative Medicine and Organ Bioengineering & Banking Roadmap Workshop, -Further developed “Solving the Organ Shortage through Organ Banking and Bioengineering,” beta roadmap report, -Invested as founder of Leucadia Therapeutics and provided grant support and assisted in closing of pre-Series A funding, -Funded large-scale efficacy study by Ichor Therapeutics, -Partnered with NASA to launch Vascular Tissue Challenge at White House Organ Summit, -Organized Vascular Tissue Challenge Roadmapping Workshop in 2016; Expanded in 2018. Funded Litmon for monitoring longevity-related scientific literature, -Launched Methuselah Fund to invest in mission-critical start-ups, -Invested as founder and Incubated Volumetric Biotechnologies (leading competitor for NASA Tissue Engineering Prize), -Invested as founder and incubated in Turn Biotechnologies, The Methuselah Foundation is a medical charity advancing…. Like other Iron Age Europeans, the early Celts maintained a polytheistic mythology and religious structure. In other words, their methodology wasn’t clinically viable for humans. In 2008 de Grey and Michael Rae published Ending Aging. "The Encyclopedia of Celtic Mythology and Folklore." The leader of the gods for the Irish pantheon appears to have been the Dagda. Scholz says, “Senescent cells seem to have a very profound impact on loss of function with age.”. It’s not a coincidence that we refer to certain kinds of computer code as ‘viruses’. Its rider held a bow, and... as people engaged in constant war "Then another horse came out, a fiery red one. Significant Irish gods include Nuada Airgetlám, the first king of the Tuatha Dé Danann; Goibniu, the smith and brewer; Dian Cecht, the patron of healing; and the sea god Manannán mac Lir. In Celtic religion: Cosmology and eschatology …in the Welsh story of Branwen, daughter of Llŷr, which ends with the survivors of the great battle feasting in the presence of the severed head of Bran the Blessed, having forgotten all their suffering and sorrow. From the beginning the Celts have been mysterious, hidden half-seen in the mists of oblivion that surround them, heroic, proud, mighty, and frightening figures when they appear in history. The Otherworld is similar to the parallel universe, usually elusive, but various mythical heroes visit it either through chance or after being invited by one of its residents. Artist. If you need to tweak a small molecule drug to alter its behavior, it could take years, and the unintended consequences of the modification (both in terms of the pharmacology and manufacturing) are far less predictable than a logic gate written in DNA.”, Scholz characterizes Oisín’s targeted DNA platform as distinct from that of pharmaceutical drug development. Gods 20; Texts 1; Warrior Hero Cu Chulainn. Tír na mBeo (Land of the Ever-Living Ones) was an ancient Irish name for the otherworld, the home of deities, spirits and ancestors. But the wind is in their sails, the water looks smooth as glass, and a new day — full of youthful promise — is dawning. Adventure, heroism, romance, and magic are a few of the elements that make Celtic mythology one of the most entrancing mythologies of Europe. [12] Some of these images can be found in Late Bronze Age peat bogs in Britain,[13] indicating the symbols were both pre-Roman and widely spread across Celtic culture. Hardcover $12.31 $ 12. In turn the Headless Horseman has become a key character used in the mythology of many other cultures, as well as in many modern horror stories. It’s easy and free to post your thinking on any topic. The other is to increase acceptance of efforts to increase human “healthspan” — years of healthy life — and lifespan. The Celtic peoples who maintained either political or linguistic identities (such as the Gaels in Ireland and Scotland, the Welsh in Wales, and the Celtic Britons of southern Great Britain and Brittany) left vestigial remnants of their ancestral mythologies that were put into written form during the Middle Ages. We know that the best way to accelerate the advent of life-saving and life-improving products and interventions is to incubate mission-driven teams and help them become companies with a focus on improving patients’ lives.” The M Fund invests private and institutional capital in companies that can tackle the following mission-oriented goals: • get rid of the crud…waste and damaged/destructive cells and structures. The New Organ Liver Prize is strongly endorsed by The Founding Fellows of the Tissue Engineering & Regenerative Medicine International Society (TERMIS). • debug the genetic code…from mutations to faulty replication, • replenish supplies…with stem cells and immune support, and. The prize has a two-fold purpose. And that conversation led to a collaboration that would become Oisín Biotechnologies. ... Highschool DxD Apocalypse Wiki is a FANDOM Anime Community. They intend to use it to treat age-related sarcopenia — the loss of muscle mass, which results in reduced strength. The short answer, as I understand it, is no. 31 $16.99 $16.99. So what’s next for Oisín Biotechnologies? Explore, If you have a story to tell, knowledge to share, or a perspective to offer — welcome home. The Foundation’s mission? With the zombie apocalypse now fast becoming a reality, Oisín Biotechnologies is keeping its sights focused on increasing lifespan and, perhaps more importantly, healthspan. Rome introduced a more widespread habit of public inscriptions, and broke the power of the druids in the areas it conquered; in fact, most inscriptions to deities discovered in Gaul (modern France and Northern Italy), Britain and other formerly (or presently) Celtic-speaking areas post-date the Roman conquest. • replace degenerated/damaged body parts…from vasculature to organs to bones. Get it as soon as Mon, Apr 5. Another application anticipated by Scholz is the use of the platform to deliver factors to rejuvenate stem cells. 3317 B.C. [14] In this he names the five principal gods worshiped in Gaul (according to the practice of his time, he gives the names of the closest equivalent Roman gods) and describes their roles: Mercury was the most venerated of all the deities and numerous representations of him were to be discovered. The more advanced versions express immune-stimulating molecules in cancer cells before killing them. This has been called into question by recent studies which show that there may have been a representation of what looks like a large drapery hanging from the horizontal arm of the figure, leading to suspicion that this figure actually represents Hercules (Heracles), with the skin of the Nemean lion over his arm and carrying the club he used to kill it. The Celtic Creation Myth. A lipid nanoparticle (LNP) is used to deliver the DNA construct to cancer cells. With this approach, there is no ‘drug’ — just a program written in DNA that tells the target cells to do something. By 2030 though? Irish tales depict the Dagda as a figure of power, armed with a club. The prophecy describes the causes as: a conquering people whose weapon was the bow "I looked, and there before me was a white horse! And more complex payloads are under development. So how does someone, who started programming computers as a kid, transition to immunology? Scholz says, “There are a lot of parallels between computer security and gene therapy. For Celts in close contact with Ancient Rome, such as the Gauls and Celtiberians, their mythology did not survive the Roman Empire, their subsequent conversion to Christianity and the loss of their Celtic languages. OncoSenX is a joint venture with Entos Pharmaceuticals. Scholz replies, “It goes back to my initial thesis — that the essence of life is information. ance. For more than a decade prior to Oisín’s founding, the Methuselah Foundation had been promoting this approach under the SENS strategy. It is mostly through contemporary Roman and Christian sources that their mythology has been preserved. This kind of logic gate is virtually impossible to build with chemistry, but it’s pretty simple with information.”, Scholz contends, “The DNA approach also allows us to adapt far faster than traditional drug development would allow for. Organovo has introduced the first architecturally correct human liver and kidney assays. Saitada was a Celtic goddess from the Tyne Valley in England whose name may mean "goddess of grief." Oisín’s delivery technology is indiscriminate — a DNA payload is delivered to any cell with which the nanoparticle fuses. Investment in efforts to increase human healthspan and lifespan has gone from very little to well over a billion dollars. “The M Fund is strategically positioned to make audacious bets in the longevity biotech startup world,” says Managing Director, Sergio Ruiz. They often … According to the legend, the world will resurface, the surviving and returning gods will meet, and the world will be repopulated by two human survivors. What has survived includes material dealing with the Tuatha Dé Danann and the Fomorians, which forms the basis for the text Cath Maige Tuired "The Battle of Mag Tuireadh", as well as portions of the history-focused Lebor Gabála Érenn ("The Book of Invasions"). Only one glance from his eye could kill. New York: Facts on File, 2004. The M Fund invests donations in startups that advance the Foundation’s mission. "Celtic Mythology: The Nature and Influence of Celtic Myth from Druidism to Arthurian Legend." The result? [3] Julius Caesar attests to the literacy of the Gauls, but also wrote that their priests, the druids, were forbidden to use writing to record certain verses of religious significance[4] (Caesar, Commentarii de Bello Gallico 6.14) while also noting that the Helvetii had a written census (Caesar, De Bello Gallico 1.29). After only two years in existence, the Methuselah Foundation introduced the world’s first longevity prize — the Mprize. [8] [9]She was known as the Morrígan, but the different sections she was divided into were also referred to as Nemain, Macha, and Badb (among other, less common names), with each representing different aspects of combat. The potent mix of signals generated is referred to as the “senescence-associated secretory phenotype.” Chronic inflammation results, tissues fail to regenerate properly, and more cells become senescent — resulting in more zombie cells. It was believed to be a place where there is no sickness or old age and where happiness lasts forever. The god appearing most frequently in the tales is Lugh. She is most commonly known for her involvement in the Táin Bó Cúailnge. While there, Scholz talked about his plan for Immusoft. The emergence of this book has been recent. He is evidently a residual of the earlier, more widespread god Lugus, whose diffusion in Celtic religion is apparent from the number of place names in which his name appears, occurring across the Celtic world. Scholz chose selective ablation of senescent cells because he considered senescent cells to be the first kind of damage to cause material harm. apocalypse... "In 1917 the Virgin Mary gave warnings and prophecies to three children in Fatima, Portugal. Blood flow is restricted, and heart failure results. Cú Chulainn was the great hero of the Ulster Cycle. More specifically, the DNA constructs contain a suicide gene (e.g., caspase 9, which is inducible or self-activating, and under the control of the p16 promoter (the “on-off” switch for the gene; p53 promoter for cancer treatment)). [11], Along with dedications giving us god names, there are also deity representations to which no name has yet been attached. Small molecule drugs can also be metabolized, and sometimes the metabolites have their own unintended or harmful effects. The Mprize has helped change that. Like the Gælic warrior-bard, Oisín Biotechnologies is in pursuit of youth. Celtic is the mythology of Celtic polytheism, the religion of the Iron Age Celts. Introduction. So, why should we try to debug life by monkeying around with its chemical substrate?”, Scholz goes on to say, “I don’t think it’s typically thought of in this light, but a damaged cell knows it’s damaged. collective term for all the fabulous profane and religious narratives of the Celts, Julius Caesar on Celtic gods and their significance, Mammoth Book of Celtic Myths and Legends|year=1999|publisher= Constable & Robinson Ltd|, Celtic Religion – What Information do we really have, What We Don't Know About the Ancient Celts, https://en.wikipedia.org/w/index.php?title=Celtic_mythology&oldid=1015253184, Wikipedia articles with SUDOC identifiers, Creative Commons Attribution-ShareAlike License, Ancient Celtic religion (known primarily through archaeological sources rather than through written mythology), This page was last edited on 31 March 2021, at 13:05. But rather than searching for an island off the western coast of Ireland, Oisín Biotechnologies is working to reverse the damage caused by the aging process, itself — with the help of the Methuselah Foundation as a founding investor. These examples seem to indicate regional preferences of a common image stock.[12]. In 2005 MIT Technology Review published a pejorative profile of de Grey and SENS. In Celtic myth, Oisín was a Gælic warrior-bard who lived in the 7th century. They were often depicted side by side with the Celtic gods. May 2, 2021 - Explore Leigh-Anne Morgan's board "CERNUNNOS" on Pinterest. The Dullahan of Celtic Mythology. The good news, obviously, is that we don’t turn into zombies. The book was well-received. Scholz thinks the platform will be used to deliver human telomerase reverse transcriptase (hTERT) mRNA to extend telomeres. See more ideas about cernunnos, celtic gods, gods and goddesses. Explore the gods and goddesses, myths, creatures and cosmology of Celtic folklore. In the case of a senescent cell, the DNA tells the cell to die via apoptosis.”. When the Methuselah Foundation came into existence, such efforts were viewed as folly, even immoral by some. But ask Gobel why he chose that mission, and he will tell you “because it’s falsifiable.”, Of greater importance to him is a commitment to a “return on mission.” In Gobel’s words, the return on mission is “how many lives are saved and how many people are not suffering that otherwise would have suffered.”. The SENSRF is based on a long-term research framework — Strategies for Engineered Negligible Senescence (SENS) — designed by de Grey to develop regenerative therapies that repair seven major classes of cellular and molecular damage associated with aging. Pooka. Telomeres protect chromosomal ends from deterioration or fusion with other chromosomes. 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